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Modified Glasgow Prognostic Score Calculator

Modified Glasgow Prognostic Score (mGPS)

Understanding the Modified Glasgow Prognostic Score

The Modified Glasgow Prognostic Score (mGPS) is a powerful inflammation-based prognostic score that predicts survival across multiple cancer types. It combines two blood markers - C-reactive protein (CRP) and albumin - to assess systemic inflammatory response and nutritional status. The score has been validated as an independent prognostic indicator, showing stronger predictive value than many other biochemical parameters.

What is the Modified Glasgow Prognostic Score?

The mGPS is calculated using:

  • C-reactive protein (CRP) level
  • Serum albumin level

The score ranges from 0 to 2, with higher scores indicating poorer prognosis:

  • Score 0: CRP ≤ 10 mg/L
  • Score 1: CRP > 10 mg/L
  • Score 2: CRP > 10 mg/L and albumin < 35 g/L

Clinical Significance

Score Interpretation

  • Score 0: Best prognosis

    • Normal inflammatory status
    • Significantly better survival rates
  • Score 1: Intermediate prognosis

    • Elevated systemic inflammation
    • Approximately 70-80% reduction in survival compared to Score 0
  • Score 2: Poor prognosis

    • Significant inflammation and poor nutritional status
    • Approximately 140-160% reduction in survival compared to Score 0

Applications

The mGPS is useful in:

  1. Cancer prognosis
  2. Treatment planning
  3. Risk stratification
  4. Clinical decision making
  5. Research settings

Important Considerations

  • Results should be interpreted by healthcare professionals
  • Score should be considered alongside other clinical factors
  • Regular monitoring may be necessary
  • Individual patient factors should be considered

When to Use mGPS

Consider calculating mGPS when:

  • Diagnosing cancer
  • Planning cancer treatment
  • Monitoring disease progression
  • Evaluating treatment response
  • Conducting research studies

Limitations

The calculator has some limitations:

  • Not specific to cancer type
  • May be affected by other inflammatory conditions
  • Should not be used in isolation
  • Requires laboratory testing

Tips for Accurate Results

  1. Use recent laboratory values
  2. Ensure correct units are selected
  3. Consider repeat testing if results are unexpected
  4. Interpret results in clinical context

Factors Affecting Results

Several factors can influence mGPS:

  • Active infection
  • Autoimmune conditions
  • Recent surgery
  • Medications
  • Liver disease
  • Nutritional status

Clinical Applications

The mGPS is valuable for:

  1. Cancer prognosis assessment
  2. Treatment planning
  3. Patient stratification
  4. Clinical research
  5. Potential universal cancer assessment tool

Start calculating now to better understand your patient's prognosis!

References:

  1. Proctor MJ, Morrison DS, Talwar D, et al. An inflammation-based prognostic score (mGPS) predicts cancer survival independent of tumour site: a Glasgow Inflammation Outcome Study. Br J Cancer. 2011;104(4):726-734.