Modified Glasgow Prognostic Score (mGPS)
Understanding the Modified Glasgow Prognostic Score
The Modified Glasgow Prognostic Score (mGPS) is a powerful inflammation-based prognostic score that predicts survival across multiple cancer types. It combines two blood markers - C-reactive protein (CRP) and albumin - to assess systemic inflammatory response and nutritional status. The score has been validated as an independent prognostic indicator, showing stronger predictive value than many other biochemical parameters.
What is the Modified Glasgow Prognostic Score?
The mGPS is calculated using:
- C-reactive protein (CRP) level
- Serum albumin level
The score ranges from 0 to 2, with higher scores indicating poorer prognosis:
- Score 0: CRP ≤ 10 mg/L
- Score 1: CRP > 10 mg/L
- Score 2: CRP > 10 mg/L and albumin < 35 g/L
Clinical Significance
Score Interpretation
-
Score 0: Best prognosis
- Normal inflammatory status
- Significantly better survival rates
-
Score 1: Intermediate prognosis
- Elevated systemic inflammation
- Approximately 70-80% reduction in survival compared to Score 0
-
Score 2: Poor prognosis
- Significant inflammation and poor nutritional status
- Approximately 140-160% reduction in survival compared to Score 0
Applications
The mGPS is useful in:
- Cancer prognosis
- Treatment planning
- Risk stratification
- Clinical decision making
- Research settings
Important Considerations
- Results should be interpreted by healthcare professionals
- Score should be considered alongside other clinical factors
- Regular monitoring may be necessary
- Individual patient factors should be considered
When to Use mGPS
Consider calculating mGPS when:
- Diagnosing cancer
- Planning cancer treatment
- Monitoring disease progression
- Evaluating treatment response
- Conducting research studies
Limitations
The calculator has some limitations:
- Not specific to cancer type
- May be affected by other inflammatory conditions
- Should not be used in isolation
- Requires laboratory testing
Tips for Accurate Results
- Use recent laboratory values
- Ensure correct units are selected
- Consider repeat testing if results are unexpected
- Interpret results in clinical context
Factors Affecting Results
Several factors can influence mGPS:
- Active infection
- Autoimmune conditions
- Recent surgery
- Medications
- Liver disease
- Nutritional status
Clinical Applications
The mGPS is valuable for:
- Cancer prognosis assessment
- Treatment planning
- Patient stratification
- Clinical research
- Potential universal cancer assessment tool
Start calculating now to better understand your patient's prognosis!
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