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Lymphocyte-to-Monocyte Ratio Calculator

Lymphocyte-to-Monocyte Ratio (LMR)

Understanding the Lymphocyte-to-Monocyte Ratio

The Lymphocyte-to-Monocyte Ratio (LMR) is a simple but valuable marker of systemic inflammation. It's calculated by dividing the absolute lymphocyte count by the absolute monocyte count. This ratio has emerged as a useful prognostic indicator in various diseases, particularly in cancer and cardiovascular conditions.

What is the Lymphocyte-to-Monocyte Ratio Test?

The LMR is derived from a complete blood count (CBC) test, which measures different components of your blood. It specifically looks at:

  • Lymphocytes: White blood cells that fight infections and diseases
  • Monocytes: White blood cells that help other white blood cells remove dead or damaged tissues

Normal LMR Values

  • Research indicates a clinical cut-off value of 5.06
  • Values below 5.06 may indicate increased cardiovascular risk
  • Values may vary between laboratories and clinical contexts

Clinical Significance

Low LMR (≤5.06)

May indicate:

  • Higher risk of severe coronary artery disease
  • Increased risk of cardiac death and non-fatal heart attacks
  • More severe atherosclerosis
  • Worse cardiovascular prognosis
  • Systemic inflammation

High LMR (>5.06)

May indicate:

  • Lower risk of severe coronary artery disease
  • Better cardiovascular outcomes
  • Less severe atherosclerosis
  • More favorable prognosis
  • Lower levels of systemic inflammation

Factors Affecting LMR

Lymphocyte counts can be affected by

  • Infections
  • Stress
  • Medications
  • Autoimmune conditions
  • Cancer treatments

Monocyte counts can be affected by

  • Chronic inflammation
  • Infections
  • Certain medications
  • Bone marrow disorders
  • Autoimmune conditions

Clinical Applications

LMR is particularly useful for:

  • Assessing severity of coronary artery disease
  • Risk stratification in cardiovascular patients
  • Evaluating atherosclerosis progression
  • Predicting future cardiovascular events
  • Monitoring treatment responses in cardiovascular disease

Start calculating now to better understand your inflammatory status!

References:

  1. Gong S, Gao X, Xu F, et al. Association of lymphocyte to monocyte ratio with severity of coronary artery disease. Medicine (Baltimore). 2018;97(43):e12813.