Corrected Calcium
Understanding Corrected Calcium
Corrected calcium is an adjusted calcium value that takes into account the effect of albumin levels on total serum calcium. This calculation is important because calcium in blood exists in two main forms - protein-bound (primarily to albumin) and ionized calcium - in roughly equal proportions. When albumin levels are abnormal, the total calcium measurement may not accurately reflect the physiologically active (ionized) calcium level.
Why Calculate Corrected Calcium?
Total serum calcium can be misleading when albumin levels are abnormal:
- Low albumin falsely lowers total calcium without affecting ionized calcium
- High albumin falsely elevates total calcium without affecting ionized calcium
- Corrected calcium provides a better estimate of the physiologically active calcium
Important Limitations
This calculator:
- Should not be used in patients with nephrotic syndrome
- May not be accurate if laboratory methods differ significantly from standard methods
- Is less reliable than direct ionized calcium measurement in critical situations
- Assumes normal acid-base status
Normal Ranges
- Corrected Calcium:
- 8.5-10.5 mg/dL
- 2.12-2.62 mmol/L
Clinical Significance
Low Corrected Calcium (Hypocalcemia)
May indicate:
- Vitamin D deficiency
- Hypoparathyroidism
- Chronic kidney disease
- Magnesium deficiency
- Certain medications
High Corrected Calcium (Hypercalcemia)
May indicate:
- Hyperparathyroidism
- Malignancy
- Sarcoidosis
- Vitamin D toxicity
- Certain medications
When to Check Corrected Calcium
- When albumin levels are abnormal
- Monitoring calcium disorders
- Evaluating symptoms of calcium imbalance
- Following parathyroid conditions
- Monitoring certain medications
Clinical Applications
Corrected calcium is particularly useful in:
- Hospital settings
- Critical care
- Outpatient monitoring
- Endocrine disorders
- Kidney disease
- Suspected hyperparathyroidism
- Older adults with unexplained symptoms
Start calculating now to better understand your calcium status!
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